FAQs

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ABOUT ZABINO

What is Zabino?

Zabino is a new health supplement made from all naturally-derived ingredients, scientifically formulated to reduce the unpleasant side-effects of drinking alcohol and to support liver function.

Zabino is formulated using a combination of B vitamins, antioxidants, electrolytes, an amino acid and herb, all of which are either depleted by alcohol intake or useful for the body to accelerate the removal of toxins after alcohol consumption, as well as improving liver function.

Where is Zabino made?

Zabino is made in Australia under GMP (Good Manufacturing Practice), as is required for therapeutic products.

Does Zabino have TGA Approval?

Zabino is classified and approved for sale as a Listed Medicine, and is regulated by the TGA (Therapeutic Goods Administration), which is Australia’s chief regulatory body.

What is Zabino made from?

Zabino is made from a scientifically formulated combination of premium, naturally-derived ingredients including B vitamins, antioxidants, electrolytes, an amino acid and herb – all of which are either depleted by alcohol intake or are useful for the body to accelerate the removal of toxins and to improve liver function.

These ingredients have all been shown in scientific and clinical studies to play a role in the physiological and chemical processes that occur within the body during and after alcohol consumption, supporting liver function and helping to reduce the unpleasant side-effects of a “hangover”.

Collectively, the ingredients in Zabino play an important role in the removal acetaldehyde (which is produced by the body when breaking down alcohol, and is the toxic substance, when in excess, most linked to hangover).

The formulation also contains a concentrated extract of Milk Thistle which has antioxidant and anti-inflammatory properties. It has been used for centuries in Western traditional herbal medicine as a liver tonic, and may help protect the liver from toxins and assist in supporting regeneration of healthy liver cells. The liver is the main detoxifying organ of the body.

Various B vitamins within the formulation can be depleted via alcohol consumption, and also play an important chemistry role in the breakdown of acetaldehyde. The B vitamins are also involved in energy production in the body and they may help decrease tiredness and support mental clarity and alertness.

The formulation contains various antioxidants that can help to decrease free radicals, (which can damage cells) that are formed during alcohol intake and its metabolism. The Zabino formulation also plays a role in supporting the body’s production of Glutathione, sometimes described as the “master anti-oxidant”. Glutathione has multiple functions within the body and has a particularly important role in the liver where it plays a direct role in the detoxification process.

Final Zabino includes electrolytes which are often depleted due to dehydration after excessive alcohol consumption. Even a small drop in normal fluid balance in the body is enough to cause headaches and fatigue. The electrolytes in Zabino assist in maintaining fluid and electrolyte balance.

Zabino contains no animal-derived ingredients, no added lactose, gluten, yeast, egg, soy or artificial flavours..

How does it work to reduce the effects of a hangover?

Alcohol is broken down in the body by enzymes, forming a chemical called acetaldehyde.  This chemical is estimated to be 40 times more toxic than alcohol and is the main reason that we feel ill after we have consumed alcohol in excess.  Acetaldehyde is also in some food products where it is a natural flavouring agent.  Some of us suffer more than others from acetaldehyde, due to quite normal genetic variability. Some of us even get red flushing in the face from acetaldehyde.  Those of us who suffer this way are more at risk from the serious adverse effects of acetaldehyde.

Alcohol (ethanol) is a chemical that is familiar to our bodies.  Evolution has given us the body chemistry that is capable of breaking down alcohol.  Our ancestors consumed alcohol from eating over-ripe fruit, and we even make about 3 grams per day of alcohol in our digestive system by food fermentation. Thus, none of us are truly alcohol-free.
That said, those of us with genetically low levels of the enzymes (called ALDH) that break down acetaldehyde in our bodies, or those who drink quickly or to excess, can overwhelm the normal capacity of their bodies to break down acetaldehyde.  Fortunately, however, Zabino can help break down the excess.

The body normally makes ADH & ALDH to relatively match the intake of alcohol & acetaldehyde respectively. However the body needs several natural substances to enable this process, including cysteine, thiamine, nicotinamide and pyridoxine, which can become depleted after alcohol consumption. All of these are contained in the all-natural formula of Zabino.

The positive effects of the ingredients in Zabino have been demonstrated in numerous research studies to assist with the metabolism of alcohol and in particular, acetaldehyde. Zabino also contains other vitamins, antioxidants, a herb, an amino and electrolytes to further assist in counteracting the unpleasant side effects of alcohol consumption.

We suggest that in addition to taking Zabino, consumers should drink water to compensate for one of the other adverse effects of alcohol, being dehydration.  This is caused by alcohol interfering with normal kidney function, causing an increase in water and electrolyte losses through excess urine production.

What hangover side effects will Zabino help with?

Zabino is scientifically formulated to reduce the unpleasant side effects that can occur after consuming alcohol. However it’s not just about avoiding a “big hangover”. Some consumers of Zabino have reported improvements in, for example, other “smaller” symptoms like interrupted sleep, fatigue, headache or nausea that they would normally get after they drink.

We believe Zabino will be extremely helpful for the vast majority of Australians who are light to moderate drinkers that may experience ill-effects of alcohol after only a couple of drinks, to now more easily enjoy a glass of wine or a beer without suffering the same unpleasant consequences the next day.

How does it work to provide liver support?

The liver is one of the largest organs in the body. It has many important metabolic functions, particularly detoxification. It converts the nutrients in our diets into substances that the body can use, stores these substances, and supplies cells with them when needed. It also takes up toxic substances and converts them into harmless substances or makes sure they are released from the body.

The liver is best known for its central role in detoxification. The liver can be thought of as a specially designed filter to remove toxic matter such as dead cells, harmful bacteria, chemicals or drugs from the bloodstream. The liver also contains various enzymes that help to breakdown other unwanted or toxic chemicals, including those created after the consumption of alcohol.

Zabino is formulated with ingredients that science has shown will improve the way the liver can manage and eliminate these toxins.

For example, Zabino contains the rate-limiting ingredients that boost the body’s production of the “master-antioxidant” glutathione, which helps the liver to eliminate toxins including acetaldehyde and other free radicals and which, when out of balance, can also result in impaired immune function.

Zabino also contains a concentrated extract of Silybum marianum (Milk Thistle), which is a natural herb that has antioxidant and anti-inflammatory properties. This has been used for centuries in Western traditional herbal medicine as a liver tonic, and may help protect the liver from toxins and assist in supporting regeneration of healthy liver cells.

Does Zabino work regardless of the type of alcohol you drink?

The mechanism of action of Zabino works on the toxins created via alcohol metabolism regardless of the alcoholic drink you consume.

However, research suggests there are some beverage-specific effects of additives or by-products such as congeners, (substances created during fermentation and giving certain alcohol its distinctive taste) in specific alcoholic beverages that may also play a role in exacerbating hangover symptoms.

The rate at which alcohol is consumed is also an important factor in the increased potential to overwhelm the body’s ability to breakdown the excess of toxins created. In this, some beverages tend to be consumed at a faster rate than others.

Will Zabino prevent intoxication?

No. If you are going to drink, please enjoy yourself, but always drink responsibly, moderately, and safely. Never drink and drive. And of course, don’t drink alcohol if you are not legally allowed to do so.

Where can I buy Zabino?

Zabino is available from selected pharmacies or online at zabino.com.au.

INSTRUCTIONS FOR TAKING ZABINO

What are the directions for taking Zabino?

To reduce the unpleasant effects of alcohol consumption, take 1 – 2 capsules with water before consuming alcohol. For best results, take an additional capsule with water before bed for every four additional drinks consumed, up to a maximum of 4 capsules per 24 hours.

When is the best time to take Zabino for maximum effect?

The best time to take Zabino is immediately before your first drink. This helps reinforce the body with what is required to eliminate the toxins created by alcohol consumption as the physiological process unfolds.

Depending on the quantity of alcohol consumed, or your individual sensitivity to alcohol’s ill-effects, you can take an additional Zabino capsule for every additional four drinks consumed, either before bed or after you have finished drinking.

We suggest taking Zabino with a full glass of water to compensate for the one of the other adverse effects of alcohol, being dehydration.

What happens if you take more than the instructed dose? Will that further assist your body in breaking down the toxins that alcohol leaves behind in your body?

When using Zabino, as a listed therapeutic medicine, you should always read the label and take only as directed.

Zabino provides and replenishes the key vitamins and nutrients that are depleted after consuming alcohol or that provide a bottleneck to toxin elimination. While individuals may vary, the dosages of these ingredients in Zabino have been carefully matched to the physiological process within the body to perform the chemistry required. Taking more Zabino, and therefore adding additional supplementation, will not necessarily assist to further accelerate the process of toxin elimination.

ABOUT HANGOVER

What IS a hangover? What is actually going on in the body when we feel hungover and how does Zabino help?

A hangover is typically referred to as the experience of various unpleasant effects following the consumption of alcohol (ethanol). Hangovers can last anywhere from several hours to more than 24 hours as the body replenishes and rebalances. Typical symptoms may include headache, drowsiness, trouble sleeping, concentration problems, nausea or simply a general feeling of being unwell and in discomfort.

What’s happening on a physiological level is that when alcohol is broken down in the body by enzymes, called Alcohol dehydrogenase (ADH), a chemical called acetaldehyde is created, which is estimated to be 40 times more toxic than alcohol and the main reason that we feel ill after we have consumed alcohol in excess.  Some of us suffer more than others from acetaldehyde, due to quite normal genetic variability, which helps to explain why some people suffer from worse hangover effects than others.

Acetaldehyde then gets slowly broken down in our bodies by ADLH enzymes. Those of us with genetically low levels of ALDH or those of us who drink alcohol quickly or to excess can overwhelm the normal capacity of our body to break down acetaldehyde.

The body normally makes ADH & ALDH to relatively match the intake of alcohol & acetaldehyde respectively. However the body needs a number of natural substances to enable this process, including cysteine, thiamine, nicotinamide and pyridoxine, which can become depleted after alcohol consumption. All of these naturally derived substances are contained in the formula of Zabino.
Zabino contains a number of natural substances that can become depleted after alcohol consumption, and through which can accelerate the detoxifying of acetaldehyde (and also reducing some of its other unwanted effects, such as oxidative stress).

The positive effects of the ingredients in Zabino have been demonstrated in research studies to assist in the metabolism of alcohol and particularly acetaldehyde.

Other factors that contribute to hangover symptoms may include dehydration, a shift in blood glucose and the depletion of various vitamins, nutrients and anti-oxidants within the body that impact other physiological processes. Zabino contains various ingredients to also help counteract these effects including electrolytes to help the hydration balance (although you should also drink plenty of water), B vitamins that are depleted as described above, and various anti-oxidants to mitigate oxidative stress. Zabino also contains ingredients, including Milk Thistle, that can support the liver, the body’s main detoxifying organ.

Why do some people get worse hangovers than others?

Research suggests that part of the reason may be genetic. Some of us suffer more than others from acetaldehyde, the chemical produced in the body when alcohol is broken down. Acetaldehyde is estimated to be 40 times more toxic than alcohol. The reason for this comes down to normal genetic variability. Some of us even get red flushing in the face from acetaldehyde. Those of us who suffer this way are more at risk from the serious adverse effects of acetaldehyde.

Physiologically, this genetic difference is at least partially based in a difference in the levels of enzymes responsible for breaking down alcohol to create acetaldehyde (ADH) and also in a difference in the enzymes that breaks down the acetaldehyde (ALDH) to form non-toxic substances that can then be removed from the body.

In terms of the background to these genetic differences, alcohol (ethanol) is a chemical that is familiar to our bodies.  Evolution has given us the body chemistry that is capable of breaking down alcohol.  Our ancestors consumed alcohol from eating over-ripe fruit, and we even make about 3 grams per day of alcohol in our digestive system by food fermentation. Thus, none of us are truly alcohol-free.

However, different ethnicities have had different levels of exposure to alcohol during their history and therefore their bodies and genetic make-ups have adapted differently. Many South-East Asians for example are, to varying degrees, lower in the capacity of their ALDH enzymes that are responsible for breaking down acetaldehyde (while in some cases they also make acetaldehyde faster). Therefore acetaldehyde accumulates faster (and longer) in their system, and they are subject to more of its ill effects, including hangover.

What other things would you suggest for folks trying to kick a hangover?

Firstly, it goes without saying, that prevention is better than cure. Avoiding drinking to excess is the obvious best alternative. It is also more difficult for the body to “undo” a hangover than to help the body detoxify along the way. This is partly why Zabino is so effective.

We suggest that you should drink water to compensate for the one of the other adverse effects of alcohol, being dehydration.  This is caused by alcohol interfering with normal kidney function, causing an increase in water and electrolyte losses through excess urine production.

However, once you have a hangover (oops), other things that may help are sugar, fats, vitamin Bs, caffeine and plenty of bed-rest for your body to quietly recuperate.